Clubbing of fingernails what does that mean

Vascular endothelial growth factor and hypertrophic osteoarthropathy. Clin Exp Rheumatol. Platelet derived growth factor PDGF may have a role. Platelets release PDGF in the vasculature of the fingertips.

PDGF stimulates growth, vascular permeability, and monocyte and neutrophil chemotaxis, and leads to proliferation of vascular smooth muscle cells and fibroblasts, as is seen in clubbing. Conditions that have chronic platelet excess e. Use of this content is subject to our disclaimer. For any urgent enquiries please contact our customer services team who are ready to help with any problems.

Evaluation of clubbing View PDF external link opens in a new window. Last reviewed: 12 Oct Last updated: 30 Jun Clubbing can be diagnosed in your healthcare provider's office. Although clubbing itself is harmless and doesn't require treatment, it is often associated with health conditions that can worsen without treatment. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life.

Krugh M, Vaidya PN. Osteoarthropathy Hypertrophic. In: StatPearls. Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial. J Orthop Translat. Chakraborty RK, Sharma S.

Secondary hypertrophic osteoarthropathy. Clubbing and hypertrophic osteoarthropathy: insights in diagnosis, pathophysiology, and clinical significance. Acta Clin Belg. Your Privacy Rights. To change or withdraw your consent choices for VerywellHealth. At any time, you can update your settings through the "EU Privacy" link at the bottom of any page. These choices will be signaled globally to our partners and will not affect browsing data.

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What to know about clubbed fingers. Medically reviewed by Kevin Martinez, M. Definition and symptoms Causes Underlying conditions Diagnosis Treatment Speaking to a doctor Summary Clubbed fingers occur when soft tissues at the fingertips become swollen and spongy. Definition and symptoms. How it happens. Underlying conditions. When to see a doctor. Exposure to air pollutants may amplify risk for depression in healthy individuals. Costs associated with obesity may account for 3.

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All about Graves' disease. Medically reviewed by Daniel Murrell, MD. Everything you need to know about heart disease. This content does not have an English version.

This content does not have an Arabic version. See more conditions. Request Appointment. Healthy Lifestyle Fingernails: Possible problems. Products and services. Slide show: 7 fingernail problems not to ignore. Previous Next 2 of 7 Nail clubbing Nail clubbing occurs when the tips of the fingers enlarge and the nails curve around the fingertips, usually over the course of years.